Obesity
Conditions
Brief summary
Hormonal disruption is the inappropriate alteration of the hormonal system by chemical substances that are present in our environment. Some chemical substances are capable of replicating, enhancing or reducing the production, release, transport or action of natural hormones. Therefore, they are called hormonal or endocrine disrupters. Some 'classic' endocrine disrupters such as pesticides and dioxins are considered responsible for infertility, cancer and thyroid problems. Recently, a number of additional chemical substances were stipulated to have endocrine disrupting capabilities. The industrial production of these substances in large quantities has led to an accumulation in our environment and thus possible negative consequences on human health. The aim of this study is to investigate the rol of these chemical substances in the occurence of overweight and obesity.
Interventions
None listed
Sponsors
Universiteit Antwerpen
University Hospital, Antwerp
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* adult * Overweight (BMI \> 25 kg/m²) or obesity (BMI \> 30 kg/²)
Exclusion criteria
* Type 1 diabetes mellitus * psychiatric illness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum levels of polychlorinated biphenyls | at the moment of entering a weight loss program | The following PCB congeners are measured (official IUPAC number is given): CB 28 CB 52 CB 74 CB 95 CB 99 CB 101 CB 105 CB 118 CB 149 CB 146 CB 153 CB 138 CB 187 CB 183 CB 128 CB 167 CB 174 CB 177 CB 171 CB 172 CB 156 CB 180 CB 170 CB 199 CB 196/203 CB 194 CB 206 CB 209 |
| Serum levels of hydroxylated metabolites of polychlorinated biphenyls | at the moment of entering a weight loss program | The following hydroxylated metabolites of polychlorinated biphenyls are measured 4-HO-CB79 4-HO-CB120 3HO-CB118 4HO-CB107 3HO-CB153 4HO-CB146 4HO-CB127 3HO-CB138 4HO-CB130 4HO-CB163 4HO-CB187 4-HO-CB162 4-HO-CB177 3HO-CB180 4HO-CB172 4HO-CB193 4-diMeO-CB202 4-HO-CB208 |
| serum levels of organochlorine pesticides | at the moment of entering a weight loss program | The following organochlorine pesticides are measured: alfa- hexachlorocyclohexane, beta-hexachlorocyclohexane, gamma-hexachlorocyclohexane Hexachlorobenzen Ocychlordane Transnonachlor p-p-dichlorodiphenyltrichloroethane, p,p'-dichlorodiphenyldichloroethylene pp-dichlorodiphenyldichloroethane |
| serum levels of polybrominated diphenyl ethers | at the moment of entering a weight loss program | The following polybrominated diphenyl ethers (BDE) are measured: BDE 28 BDE 47 BDE 100 BDE 99 BDE 154 BDE 153 BDE 183 |
| Urinary levels of pollutants | at the moment of entering a weight loss program | The pollutants detected in urine comprise of bisphenol A, triclosan, phtalates |
| Change in serum levels of polychlorinated biphenyls compared to the levels at the start of the weight loss program | after 3, 6 and 12 months of weight loss | The following PCB congeners are measured (official IUPAC number is given): CB 28 CB 52 CB 74 CB 95 CB 99 CB 101 CB 105 CB 118 CB 149 CB 146 CB 153 CB 138 CB 187 CB 183 CB 128 CB 167 CB 174 CB 177 CB 171 CB 172 CB 156 CB 180 CB 170 CB 199 CB 196/203 CB 194 CB 206 CB 209 |
| change in serum levels of hydroxylated metabolites of polychlorinated biphenyls compared to the level at the start of the weight loss program | after 3,6 and 12 months of weigth loss | The following hydroxylated metabolites of polychlorinated biphenyls are measured 4-HO-CB79 4-HO-CB120 3HO-CB118 4HO-CB107 3HO-CB153 4HO-CB146 4HO-CB127 3HO-CB138 4HO-CB130 4HO-CB163 4HO-CB187 4-HO-CB162 4-HO-CB177 3HO-CB180 4HO-CB172 4HO-CB193 4-diMeO-CB202 4-HO-CB208 |
| Change in serum levels of organochlorine pesticides compared to the level at the start of the weight loss program | after 3,6 and 12 months of weight loss | The following organochlorine pesticides are measured: alfa- hexachlorocyclohexane, beta-hexachlorocyclohexane, gamma-hexachlorocyclohexane Hexachlorobenzen Ocychlordane Transnonachlor p-p-dichlorodiphenyltrichloroethane, p,p'-dichlorodiphenyldichloroethylene pp-dichlorodiphenyldichloroethane |
| Change in serum levels of polybrominated diphenyl ethers compared to the level at the start of the weight loss program | After 3,6 and 12 months of weight loss | The following polybrominated diphenyl ethers (BDE) are measured: BDE 28 BDE 47 BDE 100 BDE 99 BDE 154 BDE 153 BDE 183 |
| change in urine levels of pollutants compared to the level at the start of the weight loss program | after 3,6 and 12 months of weight loss | The pollutants detected in urine comprise of bisphenol A, triclosan, phtalates |
Countries
Belgium
Outcome results
None listed