Cerebral Palsy, Chorioamnionitis
Conditions
Keywords
Chorioamnionitis, S100B, Brain, Neuro-development
Brief summary
Premature breaking of the amniotic fluids during pregnancy caries high risk for infection of the amniotic fluid. One of the results of chorioamnionitis is brain injury of the fetus. Fetus' brain is highly vulnerable and could be harmed even by mild inflammation before fulminant infection is developed. The aim of this study is to identify, as early as, possible signs of brain injury. S100B protein will be used as a marker for brain insult. S100b level were associated with the occurrence and size of stroke and brain trauma in adults and children. Moreover, S100B crosses the membrane and its level in women with preterm labor was associated with brain injury of preterm infant. The study question is whether the levels of S100B in women with early amniotic fluids breakdown are associated with future brain injury of the infant, as assessed by head ultrasound and neurological examination.
Interventions
None listed
Sponsors
Sheba Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Rupture of the amniotic sac before 32 weeks * Gestational age less than 32 weeks * Singleton
Exclusion criteria
* Intrauterine growth restriction * Positive TORCH * Fetus' brain malformation * Fetus' brain hemorrhage * Maternal medication with teratogenic effect
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Developmental assessment | 18 month | Developmental assessment at 18 month 1. Vineland Adaptive Behavior Scales 2. Griffith Mental Development Scales |
Countries
Israel
Contacts
Primary ContactOmer Bar - Yosef, M.D.- Ph.D.
Outcome results
None listed