Abdominal Obesity, Menopause, Obesity, Overweight, Visceral Adipose Tissue Accumulation
Conditions
Keywords
Multi-level intervention, Menopause, Body composition, Abdominal adipose tissue, Visceral adipose tissue, Perceived stress, Computed tomography, Dual energy X-ray absorptiometry
Brief summary
The aim of this study is to develop an intervention that will produce a sustained improvement in physical activity and chronic stress as a means to slow the menopause-related accumulation of visceral adipose tissue in mid-life women.
Interventions
BEHAVIORALMulti-level intervention
The development of a lifestyle program intended to intervene on the individual, social network and community over two years
Sponsors
National Heart, Lung, and Blood Institute (NHLBI)
Rush University Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
42 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Resident of the Beverly or Morgan Park neighborhood of Chicago or contiguous neighborhoods * Female * African American or Caucasian * Age 42 years or older * Intact uterus, at least one functioning ovary, at least one menstrual period in the last 12 months prior to screening. * Sufficient motivation level to make lifestyle changes, as determined by WISHFIT staff.
Exclusion criteria
* Hysterectomy * Physical activity \> 90 min per week * Metabolic conditions or use of medications that affect weight of visceral adipose tissue (diabetes, acquired immune deficiency syndrome, weight \> 300 lbs) * Presence or history of major psychiatric comorbidity (i.e. dementia, schizophrenia, bipolar disorder, alcohol/drug addiction) in the last 6 months * History of inpatient mental health treatment * Currently prescribed antipsychotic medication * History of hallucinations or bizarre thoughts * Current pregnancy * Has been told by a physician that it is unsafe to engage in physical activity * An illness expected to limit functional status or life expectancy, including: heart failure, recent heart attack, liver cirrhosis, kidney failure, oncologic conditions, history or heart surgery, angioplasty or artery stenting.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in visceral adipose tissue, as measured by CT | At two years from baseline | \<4% gain in visceral adipose tissue over a 2-year period |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effects of the multi-level intervention | At two years from baseline | Physical activity as assessed by accelerometer (min/week of \>= 3 MET) |
Other
| Measure | Time frame | Description |
|---|---|---|
| Change in body composition | At two years from baseline | * Change in waist girth and BMI * Subcutaneous and visceral adipose tissue as measured by CT * Body composition as measured by dual energy X-ray absorptiometry (fat, lean mass) |
Countries
United States
Outcome results
None listed