Genomic Human Endometrial Expression Profile
Conditions
Keywords
Endometrial priming, genomic expression. Natural cycle. Antagonist GnRH.
Brief summary
The aim of this study is to analyse genomics profile expression in endometrium under different endometrial priming for recipients.
Detailed description
We analyze the genomic profile of egg donors in different endometrial priming protocols, compared with natural cycle, including the conventional single long acting GnRH agonist injection in the mid luteal phase of the previous cycle of the endometrial priming and the single daily antagonist injection (Cetrorelix 0.25 mg) administered in the early follicular phase followed by endometrial priming. Endometrial biopsy will be taken in luteinizing hormone * 7 or with P4 +5 in cases with endometrial priming with oestrogens therapy.
Interventions
PROCEDUREendometrial biopsy
endometrial biopsy
Sponsors
Igenomix
Instituto Valenciano de Infertilidad, IVI VALENCIA
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* 6 egg healthy volunteer egg donors. * Volunteers. * 18-35 years old * Healthy. * BMI \<28.
Exclusion criteria
* \- BMI \> 28 * Smokers-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| genetic endometrial human profile expression | Oocyte donors will be followed up for four to six months | implantation related genes profile expression |
Countries
Spain
Outcome results
None listed