The Role of Mid-Life Adiposity in Functional Brain Connectivity

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01777789

Enrollment

Registered

2013-01-29

Start date

2012-12-31

Completion date

2016-02-29

Last updated

2016-02-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer's Disease

Keywords

fMRI, Dementia, Alzheimer's disease, functional neuroimaging, Memory

Brief summary

The purpose of the study is to use functional MRI (fMRI) to measure brain connectivity in middle-aged individuals with different levels of body fat. The ultimate goal of this research is to develop an early diagnostic tool for Alzheimer's disease.

Detailed description

Participants will have one visit for: * Blood draw * Body composition scan * Cognitive screen * Neurological exam * MRI scan The visit will take approximately 3 hours.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

45 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* 45-65 years of age * Normal memory * Right-handed * General good physical health

Exclusion criteria

* History of stroke or neurological disease * Seizures or head injury with loss of consciousness within the last five years * Ferrous (magnetic) or electronic implants (due to the magnet in the MRI scanner) * Claustrophobia More detailed inclusion/

Design outcomes

Primary

Measure	Time frame
Brain connectivity measured by fMRI	One visit

Countries

United States

Outcome results