Change of Transit or Circulation, Effects of Immunosuppressant Therapy
Conditions
Keywords
Renal transplant, Gastrointestinal motility, Biomagnetism
Brief summary
Gastrointestinal (GI) complications after renal transplantation are commonly reported as side effects of immunosuppressive agents. Despite this, motility disorders have been scantily studied. Alternating Current Biosusceptometry (ACB) are biomagnetic sensors designed for a wide range of applications. In clinical practice, their non-invasive and radiation free features provide an excellent approach for monitoring of GI transit as alternative to scintigraphy and breath tests. The aim of this study is to examine GI transit and motility of solids in stable renal transplant recipients to determine the potential influence of immunosuppressive therapy on gastrointestinal parameters.
Interventions
None listed
Sponsors
UPECLIN HC FM Botucatu Unesp
University of Sao Paulo
Universidade Estadual de Ciências da Saúde de Alagoas
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy Volunteer or Renal Transplant Patients * Signed informed consent obtained * Fasted since midnight
Exclusion criteria
* Subject has known GI related symptoms complaints or GI diseases * Subject has cancer or other life threatening diseases or conditions * Subject is pregnant * Subject has undergone abdominal surgery * Drug abuse or alcoholism * Subject has cardiac pacemaker * Subject takes any medication affecting GI motility
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Influence of tacrolimus and cyclosporine on gastrointestinal transit | one year |
Countries
Brazil
Contacts
Primary ContactMaria do Carmo B Teixeira, PhD
Outcome results
None listed