Comparison of Standard Versus Low Bicarbonate Hemodialysis

Intradialytic Acid-base Changes and Organic Anion Production With Standard Versus Low Bicarbonate Hemodialysis

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01777178

Enrollment

Registered

2013-01-28

Start date

2013-01-31

Completion date

2013-06-30

Last updated

2019-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Kidney Disease, Metabolic Acidosis

Keywords

bicarbonate, dialysis

Brief summary

This study will compare acid-base changes during hemodialysis treatments with a standard dialysis bath versus a lower bicarbonate dialysis bath, and aims to define the factors that limit equilibration of the bicarbonate concentration in a patient's blood with that in the dialysate.

Interventions

OTHERLow bicarbonate dialysis

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

19 Years to No maximum

Healthy volunteers

Inclusion criteria

* Receiving chronic thrice-weekly conventional hemodialysis for at least 3 months * Age \> 18 years

Exclusion criteria

* Use of oral alkali within the previous month * Hospitalization within the previous month * Inability to provide written informed consent * Pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Change in beta-hydroxybutyrate clearance	1-2 weeks	Comparison between 2 hemodialysis treatments with different bicarbonate dialysis concentrations
Change in lactate clearance	1-2 weeks	Comparison between 2 hemodialysis treatments with different bicarbonate dialysis concentrations
Post-dialysis pH	1-2 weeks	—
Post-dialysis bicarbonate	1-2 weeks	—

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026