Type 2 Diabetes
Conditions
Keywords
type 2 diabetes, nutrition, fibers
Brief summary
In animal models and retrospective studies, certain food components such as sugars and fiber have been detected as potential agents to influence development and progress of type 2 diabetes. The DiNA study prospectively investigates, if non-soluble non-fermentable fibers (vs. soluble ones) and galactose (vs. palatinose) are capable to improvement metabolic parameters in patients with long-term type 2 diabetes and intensive insulin treatment.
Interventions
DIETARY_SUPPLEMENTDietary supplement (4 arms, 2 active, 2 placebo)
Sponsors
Firma Rettenmeier & Söhne (Company)
German Center for Diabetes Research
German Institute of Human Nutrition
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 79 Years
Healthy volunteers
No
Inclusion criteria
* type 2 diabetes, insulin-dependent * high insulin resistance
Exclusion criteria
* accompanying disease, medication or metabolic disorder, which interact with glucose metabolism or eating behavior (e.g. renal insufficiency, major cardial insuffiency, untreated hypothyreosis, corticoid treatment, depression and other psychiatric disorders...)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| metabolic improvement of type 2 diabetes | 4 weeks | metabolic improvement of type 2 diabetes, as to be shown via hyperinsulinemic-euglycaemic clamp, mixed-meal test and daily demand of insulin units |
Countries
Germany
Outcome results
None listed