Metabolism, Weight Loss
Conditions
Keywords
Energy, Metabolism, Weight Loss, Exercise
Brief summary
The E-MECHANIC Ancillary Study will measure changes in 24-hour energy expenditure and spontaneous physical activity in a subset of 60 obese individuals enrolled in the main study. We aim to determine if changes in energy metabolism might explain why people don't lose the expected amount of weight in an exercise program.
Detailed description
This is an ancillary study to E-Mechanic, which is an National Institutes of Health study in 198 individuals with the objective to understand why certain people fail to lose weight in exercise programs. In E-Mechanic changes in body weight, body composition, energy intake and energy expenditure are measured before and after 3 different exercise programs of 24 weeks in duration. The 3 exercise programs being compared are self-directed exercise, low dose exercise and high dose exercise. The goal of this ancillary study is to undertake comprehensive assessments of energy metabolism in a metabolic chamber in a group of 60 obese individuals enrolled in the main study. We will compare differences in the changes in 24h energy expenditure and spontaneous physical activity between the 3 exercise programs. We will also test if changes in energy metabolism might explain why people don't lose the expected amount of weight after 24 weeks of exercise.
Interventions
None listed
Sponsors
Pennington Biomedical Research Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Individuals enrolled in the E-MECHANIC main study (NCT#01264406) with a body mass index (BMI) greater than or equal to 30 kg/m2.
Exclusion criteria
* Not enrolled in the E-MECHANIC main study (NCT#01264406). * Have a body mass index (BMI) less than 30 kg/m2.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in 24h energy expenditure | 24 weeks | 24h energy expenditure will be measured in a room calorimeter before and after a 24 week exercise program |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Metabolic adaptation in 24h energy expenditure | 24 weeks | The difference between the actual change in 24 energy expenditure and the energy expenditure estimated on the basis of body size will be compared between: 1) exercise groups and 2) between individuals who lost the expected amount of weight and individuals who did not lose the expected amount of weight during the exercise program |
Other
| Measure | Time frame | Description |
|---|---|---|
| Sleeping energy expenditure | 24 weeks | Sleeping energy expenditure will be measured in a room calorimeter before and after a 24 week exercise program |
| Spontaneous physical activity | 24 weeks | Spontaneous physical activity will be measured in a room calorimeter before and after a 24 week exercise program |
Countries
United States
Outcome results
None listed