Respiratory Function and Walking Capacity in Multiple Sclerosis

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01774201

Enrollment

Registered

2013-01-23

Start date

2012-09-30

Completion date

2014-12-31

Last updated

2017-01-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Difficulty Walking, Multiple Sclerosis, Respiratory; Disorder, Functional, Impaired

Keywords

Multiple sclerosis, Self-assessment, Physical endurance, Respiratory function, Fatigue

Brief summary

Multiple sclerosis (MS) is a chronic progressive neurological disease. Respiratory dysfunction due to weakness in the respiratory musculature has been described in MS. This leads to increased morbidity and mortality in late stages of the disease. It is possible that respiratory dysfunction influence physical fitness in earlier stages as well. Walking disability and fatigue causes significant impact on health in patients with MS, even in earlier stages. The hypothesis is that there is a relationship between respiratory function, walking capacity and fatigue and that daily deep breathing exercise during two months will improve respiratory function, walking capacity and fatigue.

Detailed description

Presented above.

Interventions

OTHERBreathing exercises

Breathing exercises with positive expiratory pressure.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Investigator)

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Inhabitant in Orebro county, Sweden, that are diagnosed with MS according to the revised McDonald criteria and registered in the Swedish MS-registry with EDSS (Expanded disability status scale) score in the interval ≥ 3.0 - ≤ 7.0. * Participants must understand verbal and written information and must be relapse free ≥ 3 months prior to inclusion.

Exclusion criteria

* Patients with diseases that may have influence on walking ability and respiratory function (other than MS). Such conditions include heart and lung diseases, orthopedic disorders, patients recently subjected to surgery, and non-MS related neurological dysfunction.

Design outcomes

Primary

Measure	Time frame	Description
Respiratory muscle strength	Two months	Maximum expiratory pressure

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026