Other Complications Associated With Artificial Fertilization
Conditions
Keywords
In vitro fertilization, Embryo transfer, Embryo culture, individual culture, Group culture, embryo quality, Pregnancy rate, Implantation
Brief summary
Prospective randomized comparison of two widely used in vitro culture system in human IVF treatments. In vitro fertilized oocytes and embryos are cultured in individual culture media droplets using conventional petridish or in group culture using WOW (well of the well) petridish. Primary outcome: implantation and pregnancy rates Secondary outcome: fertilization rate and embryo quality
Interventions
OTHERindividual embryo culture or group culture
Embryos cultured in a 25 microliter droplet of culture media individually in a conventional petridish or in groups of 2-10 embryos in a Well-of-the-Well petridish
Sponsors
Semmelweis University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Infertile patients entering in vitro fertilization treatment * at least 1 oocyte collected
Exclusion criteria
* no oocytes collected
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical pregnancy rate | 4 weeks after the embryo transfer | Number of clinical pregnancies (/No. of embryo transfers) |
| Implantation rate | 4 weeks after embryo transfer | Number of embryos implanted (/number of embryos transferred) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Fertilization rate | 18 hours after sperm injection | Number of oocytes fertilized. (only in intracytoplasmic sperm injection cycles) |
| Embryo quality | 36 and 72 hours after fertilization | Number and quality of blastomeres, amount of fragmentation embryo grade |
Other
| Measure | Time frame |
|---|---|
| Time needed for evaluation of zygotes and embryos | 18, 24, 36 and 72 hours after fertilization |
Countries
Hungary
Outcome results
None listed