Infertility
Conditions
Keywords
Time-lapse, morphokinetics, blastocyst transfer, eSET
Brief summary
Choosing the best embryo for transfer has become the major challenge in in vitro fertilization (IVF). Morphology alone is obviously not enough and time-lapse incubation has added embryo development kinetics as another selection criterion. This study was designed to select for the top blastocyst to be replaced, while increasing the pregnancy chance, with the local legislation regulating the number of embryos to be transferred and to establish a morphokinetic standard to be used in our clinical setting.
Interventions
DEVICEEmbryoscope
Five-day embryo culture in embryoscope which is an incubator with a built-in camera
Sponsors
Dr. Murat Çetinkaya
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* patients in their first or second ART treatment cycle * no recurrent spontaneous abortions * age\<35 years * BMI\<28 kg/m2 * ≥8 oocytes retrieved
Exclusion criteria
* severe endometriosis * polycystic ovary syndrome * hydrosalpynx * uterine pathology * severe male factor (presenting less than 5 million motile sperm cells in total in the ejaculate) * very severe morphological sperm defects (mainly globozoospermic or macrocephalic samples)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blastocyst formation rate | 5th day of embryonic development |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical pregnancy rate | 7th week of pregnancy | Clinical pregnancy was defined as the presence of a gestational sac detected on ultrasound 3 weeks after the first βhCG test, which was performed 14 days after oocyte retrieval. |
Countries
Turkey (Türkiye)
Outcome results
None listed