Obesity
Conditions
Keywords
Obesity, Body Weight, Body Composition, Metabolism, Resting Energy Expenditure
Brief summary
The objective of this study is to test the effect of dihydrocapsiate on energy expenditure in women.
Detailed description
Capsaicin, a substance found in chili pepper, is known to stimulate thermogenesis. Dihydrocapsiate, a capsinoid, found in the non-pungent CH-19 sweet pepper has similar thermogenic effects without the gastrointestinal side effects. The objective of this project is to test the effect of 12 weeks of daily consumption of 9 mg dihydrocapsiate on resting energy expenditure relative to baseline when compared to a control group consuming products without DCT.
Interventions
DIETARY_SUPPLEMENTDihydrocapsiate
Kellogg's ready to eat cereal, cereal bars, and crackers will contain dihyrocapsiate or placebo. Daily consumption of dihydrocapsiate is 9mg/d or 0mg/d.
Sponsors
Kellogg Company
Ellen Evans
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
25 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI: 18.5-34.5 kg/m2 * Good general health * Low to mild physical activity * Willing to maintain habitual diet and physical activity patterns throughout the study period * Premenopausal and cycling regularly or using oral contraceptives * Willing to attend study visits only during the follicular phase or bleed phase of their menstrual cycle * Understands study procedures and signs forms providing informed consent to participate in the study * Have spoken and written English literacy
Exclusion criteria
* Diabetes mellitus or any conditions that might affect energy metabolism * Weight change ±2 kg over previous three months * Known sensitivity or allergy to ingredients of the study products * Non-breakfast eater * Recent use of antibiotics * History of smoking during the six months prior to study * Recent signs or symptoms of infection, including cold or flu-like symptoms * Concurrent or recent intervention study participation * Instability in breathing patterns or energy expenditure measures * History of drug or alcohol abuse * Lipid-lowering, anti-hypertensive or anti-inflammatory steroid medication use * Weight loss medication * Pregnant or lactating * Unwilling to be randomized to any experimental group and unable to meet all requirements of the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resting Energy Expenditure | Change from Baseline at 12 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Thermic effect of feeding | Change from baseline at 12 weeks |
| Body Composition | Change from baseline at 12 weeks |
Countries
United States
Outcome results
None listed