Pain on Injection of Propofol,Lidocaine, Alkalinized Lidocaine
Conditions
Brief summary
Aim: The aim of this study was to compare the efficacy of pretreatment 0.5 mg/kg lidocaine and 0.5 mg/kg alkalinized lidocaine for prevention of propofol induced pain. Methods: In this double-blind, placebo controlled study, 300 adults patients ASA I or II, scheduled to undergo elective surgery, were randomly assigned into three groups of 100 each. Group L, recevied 0.05 mL/kg lidocaine (% 2 lidocaine 5 mL + 5 mL SF), Group A, 0.05 mL/kg lidocaine with bicarbonate ( % 2 lidocaine 5 mL + 1 mL %8,4 NaHCO3+ 4 mL SF) and control group received isotonic saline pretreatment in the dorsum of the hand, followed by propofol 30 sec later. A blinded researcher assessed the patient's pain level via a four-point scale.
Interventions
recevied 0.05 mL/kg lidocaine with bicarbonate ( % 2 lidocaine 5 mL + 1 mL %8,4 NaHCO3+ 4 mL SF)
DRUGLidocaine
0.05 mL/kg lidocaine (% 2 lidocaine 5 mL + 5 mL SF),
DRUGPlacebo (for alcalinized lidocaine)
Sponsors
Inonu University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* undergoing elective surgery
Exclusion criteria
* allergy to the study drug
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain on injection of propofol | 5 th minutes after propofol injection |
Countries
Turkey (Türkiye)
Outcome results
None listed