Effects of Phenolic Acids on Endothelial Function

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01772784

Enrollment

Registered

2013-01-21

Start date

2012-06-30

Completion date

2012-11-30

Last updated

2013-01-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

subjects

Brief summary

Epidemiological studies suggest dietary (poly) phenols decrease the risk of death from cardiovascular diseases. (Poly)phenol-rich foods include fruits and vegetables as well as tea, coffee, red wine, and chocolate. The aim of the present study is to investigate whether endothelial function is altered by ingestion of phenolic acids. Moreover, the investigators will evaluate the effect of phenolic acids on blood pressure and platelet adhesion.

Interventions

OTHERPhenolic acids

Phenolic acids

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

MALE

Age

18 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy * males * Smokers

Exclusion criteria

Any food allergy * Abnormal blood pressure defined as follow: systolic \<100 or \>160 mmHg and diastolic \<50 or \>100mmHg * Regular consumption of medication within 2 months before the study inclusion * Caffeine intake 1 day before screening measurements (and 1 day before each visit), * Any intake of multivitamin-tablets and other supplemental compounds 10 days before the study start and throughout the study. * Excessive alcohol intake defined as \> 280 g per week

Design outcomes

Primary

Measure	Time frame
endothelial dysfunction	1 hour

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 11, 2026