Dexamethasone in Prevention of Respiratory Morbidity in Elective Caesarean Section in Term Fetus

Dexamethasone in Prevention of Respiratory Morbidity in Elective Caesarean

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01772381

Enrollment

600

Registered

2013-01-21

Start date

2010-03-31

Completion date

2011-06-30

Last updated

2013-01-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Transient Tachypnea of the Newborn

Keywords

Dexamethasone, term, elective cesarean section

Brief summary

Introduction: Babies born at term by elective caesarean section (CS) and before onset of labor are more likely to develop respiratory complications than babies born vaginally. In developing countries resources are scarce and it is difficult to provide expensive treatments as neonatal care. Aim of the Work: To assess the effect of prophylactic dexamethasone administration before elective cesarean section at term in reducing neonatal respiratory complications. Patients and methods: 600 women were included in the study and were planned to have elective caesarean section. 300 received dexamethasone 12 mg twice, 12 hours apart 48 hours before delivery. 300 patients were the control group. The outcomes were: incidence of admission to neonatal intensive care unit (NICU), incidence of transient tachypnea of newborn (TTN), the incidence of respiratory distress syndrome (RDS) and the need for mechanical ventilation.

Detailed description

Dexamethasone which is a long acting corticosteroid can be used prior to elective cesarean section to decrease neonatal respiratory morbidity by enhacing fetal lung maturity.

Interventions

DRUGDexamethasone

Long acting corticosteroid

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

22 Years to 44 Years

Healthy volunteers

Yes

Inclusion criteria

* Previous caesarean section * Complete 37 week calculated from the first day of the last menstrual period.

Exclusion criteria

* Obstetric complications such as pre-eclampsia, antepartum hemorrhage or known fetal anomaly. * Hypertensive patients. * Chronic disease e.g. diabetes mellitus. * Known renal disease. * Pre-operative infection.

Design outcomes

Primary

Measure	Time frame	Description
Special care baby unit	24 hours	Special care baby unit admission for babies with respiratory distress

Secondary

Measure	Time frame	Description
Severity of respiratory distress	24 hours	Severity of respiratory distress and the level of care in response

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026