Skin Lesion
Conditions
Brief summary
The purpose of this pilot study is to employ multiphoton microscopy to non-invasively image in-vivo pigmented and non-pigmented human skin lesions for characterization of their morphologic and functional features.
Detailed description
This study is performed using a multiphoton microscopy-based tomograph (MPTflex) developed by JenLab, GmbH (Germany) and a MPM imaging system developed at BLI: Fast Large Area Multiphoton Exoscope (FLAME) to image non-invasively normal and lesional skin. Skin lesions are imaged by multiphoton microscopy and images are compared to those obtained from histopathology through standard of care processed skin biopsies. Any biopsies will be performed by the health care provider as a standard of care procedure.
Interventions
DEVICEMultiphoton microscopy-based tomograph.
non-invasive optical biopsy
Sponsors
University of California, Irvine
National Institute for Biomedical Imaging and Bioengineering (NIBIB)
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Male or Female all age groups * Ability to understand and carry out subject instructions
Exclusion criteria
* Pregnant women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| high-resolution images of skin | up to 12 months | The complementary imaging modalities (MPM, MI) will provide insights into a better understanding of the relationship between microscopic and macroscopic properties of the skin. |
Countries
United States
Contacts
CONTACTHanna Kim
CONTACTMihaela Balu, PhD
PRINCIPAL_INVESTIGATORKristen Kelly, MD
Beckman Laser Institute, UCI
Outcome results
None listed