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Effects of Phototherapy by Low-level Light-emitting Diode Therapy (LEDT) on Clinical, Biochemical, Biomechanical, Histologic and Genetic Responses of Muscle Performance of Young Males Submitted to Physical Strength Training

Effects of Phototherapy by Low-level Light-emitting Diode Therapy (LEDT) on Clinical, Biochemical, Biomechanical, Histologic and Genetic Responses of Muscle Performance of Young Males Submitted to Physical Strength Training

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01770938
Enrollment
32
Registered
2013-01-18
Start date
2012-05-31
Completion date
2014-09-30
Last updated
2014-09-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

Light-emitting diode therapy, Muscle performance, Gene expression, Functional performance

Brief summary

Muscle performance is largely influenced by modulations in gene expressions of muscle tissue. In this context, light-emitting diode therapy (LEDT) has been used to improve muscle performance in experimental models and human researches. Thereby, the investigators examined modulations in gene expression of muscle tissue as well as biochemical, biomechanic and histologic adaptations influenced by exercise associated to LEDT.

Detailed description

This study assessed muscle performance in isokinetic dynamometry and led press device, gene expression by RT-PCR, lactate, creatine kinase and morphology of muscle tissue by immunohistochemical analysis

Interventions

DEVICEEffective light-emitting diode therapy
DEVICEPlacebo light-emitting diode therapy

Sponsors

Fundação de Amparo à Pesquisa do Estado de São Paulo
CollaboratorOTHER_GOV
Centro de Pequisas de Ótica e Fotônica
CollaboratorOTHER
Universidade Federal de Sao Carlos
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
MALE
Age
18 Years to 28 Years
Healthy volunteers
Yes

Inclusion criteria

* healthy males aged between 18 and 28 years with a body mass index (BMI) equal to or less than 26 kg/m2, * moderated pattern of physical activity

Exclusion criteria

* previous injury to the femoral quadriceps or hamstring muscles (within 6 months prior to study), * osseous or articular disorder in the lower limbs, * cardiovascular system disorders, * systemic disease, and * taking prescription medicines or using dietary supplements such as muscle mass builders.

Design outcomes

Primary

MeasureTime frame
Modulations on muscle gene expression by RT-PCR12 weeks

Secondary

MeasureTime frameDescription
Muscle performance in leg press device12 weeks—
Muscle performance in leg extension device12 weeks—
Muscle performance in isokinetic dynamometer12 weeks—
Gene expression12 weeksGene expression of muscle tissue by RT-PCR

Other

MeasureTime frameDescription
Immunohistochemical analysis12 weeksImmunohistochemical analysis to quantify morphology and cells of muscle tissue as satellite cells.

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026