Arterial Stiffness in Chronic Kidney Disease

Diurnal Variations in Arterial Stiffness in Patients With Chronic Kidney Disease and Healthy Age Matched Controls

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01770847

Enrollment

Registered

2013-01-18

Start date

2012-11-30

Completion date

Unknown

Last updated

2017-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Kidney Disease

Brief summary

Diurnal variations in the cardiovascular system apparent in healthy individuals, are different in chronic kidney disease patients. Therefore, diurnal variations in arterial stiffness may also differ in chronic kidney disease patients. This study aims to identify and evaluate diurnal variations in arterial stiffness in chronic kidney disease patients and compare them to those in age matched healthy controls.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 79 Years

Healthy volunteers

Yes

Inclusion criteria

* Systolic blood pressure \<160 whether or not on antihypertensive medication * diastolic blood pressure \<100mmHg whether or not on antihypertensive medication * Chronic kidney disease stage 2-5

Exclusion criteria

* Systolic blood pressure ≥160mmHg * Diastolic blood pressure ≥100mmhg * Significant comorbidity (investigator opinion but to include alcoholism and terminal illness)

Design outcomes

Primary

Measure	Time frame	Description
Diurnal variations in arterial stiffness	Over one 26 hour period arterial stiffness measurements will be obtained every 30 minutes from 7am to 12am and every 60 minutes from 12am to 7am	The principal objective of this study is to evaluate whether diurnal variations in arterial stiffness are blunted in chronic kidney disease compared to healthy age matched controls

Secondary

Measure	Time frame	Description
Diurnal variations in aortic and brachial blood pressure	Over one 26 hour period blood pressure measurements will be obtained every 30 minutes from 7am to 12am and every 60 minutes from 12am to 7am	Secondary objective of this study is to evaluate whether diurnal variations in aortic and brachial blood pressure are blunted in chronic kidney disease compared to healthy age matched controls
Relationship between changes in blood pressure and arterial stiffness	Over one 26 hour period	Secondary objective of this study is to evaluate whether diurnal variations in arterial stiffness are dependent on changes in blood pressure in both chronic kidney disease patients and age matched controls.

Countries

United Kingdom

Outcome results