Septic Shock
Conditions
Keywords
ICU population
Brief summary
This study is designed to examine the early sequential cytokine responses during antibiotic therapy and resuscitation of septic shock in relation to clinical manifestations of disease. The specific objective is to obtain sequential serum samples from patients with septic shock, examine a broad range of cytokine responses (TNF, IL-1, IL-6, MIF, LIF, HMGB1, etc) in a rigorous manner and correlate these responses to administration of antibiotics, resuscitative efforts and physiologic responses to illness (temp, HR, blood pressure, WBC, etc).
Detailed description
Patients must be on vasopressors Patients cannot be on pressors for \> 24 hrs prior to consent
Interventions
None listed
Sponsors
University of Manitoba
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult ICU patients: . 18 years admitted with septic shock * Receiving Vasopressors \< 24 hrs
Exclusion criteria
* Consent refused by patient or SDM * Received Vasopressors \> 24hrs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cytokine response in septic shock | Hours 0, 3, 6, 12, 18, 24, 36, 48, 96 and day 7 | his study is designed to examine the early sequential cytokine responses during antibiotic therapy and resuscitation of septic shock in relation to clinical manifestations of disease. The specific objective is to obtain sequential serum samples from patients with septic shock, examine a broad range of cytokine responses (TNF, IL-1, IL-6, MIF, LIF, HMGB1, etc) in a rigorous manner and correlate these responses to administration of antibiotics, resuscitative efforts and physiologic responses to illness (temp, HR, blood pressure, WBC, etc). |
Countries
Canada
Contacts
Primary ContactAnand Kumar, MD
Backup ContactWendy Janz, RN
Outcome results
None listed