Ventilator Acquired Pneumonia
Conditions
Keywords
patient ventilated for at least five days
Brief summary
Ventilator acquired pneumonia (VAP) are severe nosocomial infections. On the other side, bronchial fungi colonization is commonly observed in ICU; therefore, the investigators propose to study the role of bronchial fungi colonization on the occurrence of VAP taking into account the immune status of the patient and the antibiotic and antifungal treatments he has received.
Interventions
PROCEDUREbiological sampling
cutaneous, rectal, nose and mouth swabs to identify potential fungi colonization
PROCEDUREsampling blood
HLA DR antigen, cytokines (IL 6 and 10), B-glucan
PROCEDUREendotracheal aspiration
fungi and bacteria endotracheal aspiration
Sponsors
University Hospital, Grenoble
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patient ventilated for at least 5 days
Exclusion criteria
* invasive infection Candida sp defined by : candidemia, isolation of Candida from a normally sterile site, candida pneumoniae.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Onset of a late ventilator acquired pneumonia (VAP) | Participants will be followed for the duration of mechanical ventilation, an expected time frame that can go from 5 days to up to 8 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Onset of a pseudomonas aeruginosa associated VAP | Participants will be followed for the duration of mechanical ventilation, an expected time frame that can go from 5 days to up to 8 weeks |
| Onset of late ventilator associated pneumonia associated to staphylococcus aureus | Participants will be followed for the duration of mechanical ventilation, an expected time frame that can go from 5 days to up to 8 weeks |
Countries
France
Outcome results
None listed