Insulin Resistance
Conditions
Brief summary
The aim of this study is to examine whether periodic fasting improves markers of diabetes risk and cardiovascular health, and will compare this to the effects observed with daily dieting by energy restriction, and also with no change in energy intake. It is hypothesized that periodic fasting, with or without weight loss, will be as effective as daily energy restriction to improve markers of metabolic health and energy metabolism.
Interventions
Sponsors
University of Adelaide
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
35 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Body mass index (BMI) between 25 and 42 kg/m2 * weight stable (\<5% fluctuation in body weight for the 6 months prior to study entry)
Exclusion criteria
* history of cardiovascular disease, diabetes, major psychiatric disorders, and eating disorders * use of prescribed or non-prescribed medications with may affect energy metabolism, gastrointestinal function, body weight, or appetite * recent weight changes in 3 months prior to study entry * uncontrolled asthma, current fever, upper respiratory infections * individuals who regularly perform high intensity exercise (\>2 sessions per week) * pregnancy, lactation (breast feeding), women who are planning to become pregnant * current intake of \>140g of alcohol per week * current smoker of cigarettes/cigars/marijuana * current intake of any illicit substance * experience claustrophobia in confined spaces * has donated blood within the past 3 months * unable to comprehend the study protocol * experiences migraines
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Insulin sensitivity | 8 weeks | assessed by hyperinsulinemic euglycemic clamp |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Plasma hormones and adipokines | 8 weeks | — |
| Cognitive function, hunger, and mood | 8 weeks | — |
| Oxidative stress, stress resistance, and lipid metabolism | 8 weeks | — |
| Energy expenditure | 8 weeks | resting energy expenditure, and total daily energy expenditure |
Countries
Australia
Outcome results
None listed