Obstructive Sleep Apnea
Conditions
Keywords
Sleep apnea, CPAP treatment, Plasma nitrate, Urinary norepinephrine, Blood pressure
Brief summary
Reduced plasma nitrate (NOx) levels and increased urinary norepinephrine (U-NE) levels have been described in severe obstructive sleep apnea (OSA), and are reverted by continuous positive airway pressure (CPAP). The investigators wanted to know the effect of CPAP on these biomarkers in mild-moderate OSA.
Detailed description
The investigators aimed to compare NOx and U-NE levels and blood pressure (BP) between male patients with mild-moderate and severe OSA and determine the impact of 1 month of CPAP therapy on these parameters. The investigators undertook a prospective study of 67 consecutive OSA patients (36 mild-moderate, 31 severe). Measurements of plasma NOx at 11 pm, 4 am and 7 am, 24-h U-NE and ambulatory BP were obtained at baseline and after 1 month of CPAP.
Interventions
DEVICECPAP
CPAP adaptation was performed by a sleep technician and the patients were instructed to use this for 1 month.
Sponsors
University of Lisbon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
\- Diagnosis of obstructive sleep apnea
Exclusion criteria
* current smoker * respiratory disease * cardiac disease (except for arterial hypertension) * renal disorder * hepatic disorder * psychiatric disorder * diabetes mellitus * dyslipidemia * rhinitis * sinusitis * acute illness * daytime hypoxemia or hypercapnia * therapy with oral nitrates * therapy with angiotensin-converting enzyme inhibitors * therapy with beta-blockers * therapy with statins * therapy with non-steroidal anti-inflammatory drugs * presence of central respiratory events * previous CPAP therapy * previous uvulopalatopharyngoplasty
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Plasma nitrate (NOx) levels | one month | After sleep apnea diagnosis, measurements of plasma NOx at 11 pm, 4 am and 7 am were obtained at baseline and after 1 month of CPAP. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 24 h Blood pressure | one month after CPAP | Ambulatory BP were obtained at baseline and after 1 month of CPAP. |
| Urinary norepinephrine (U-NE) levels | One month | After sleep apnea diagnosis, measurements of urinary norepinephrine levels were obtained at baseline and after 1 month of CPAP. |
Countries
Portugal
Outcome results
None listed