Obesity, Sarcopenia
Conditions
Keywords
resistance exercise, muscle mass, abdominal fat, strength, Coronary Heart Disease (CHD)-risk, myocardial mass
Brief summary
A plethora of trials reported the positive effect of resistance exercise on functional and morphological parameters. Although a large amount of the studies used suboptimum devices and obsolete methods the results of these older studies were still considered as golden standard. The aim of the present study is thus to determine the proper effect of different resistance exercise protocols with and without adjuvant protein supplementation on functional and morphological muscle and body composition parameters in male untrained subjects 30-50 years old under special regard of modern medical imaging and segmentation technologies. Our general study hypothesis is that HIT-resistance exercise significantly impact relevant muscular parameters of the upper leg.
Interventions
OTHERHIT-exercise, low repetition range
High Intensity Resistance Exercise Training, low repetition range, \> 75% 1RM
OTHERHIT-exercise, high repetition range
High Intensity Resistance Exercise Training, high repetition range, 60 - \< 75 1RM
OTHERHIT-exercise with protein
High Intensity Resistance Exercise Training, low repetition range, \> 75% 1RM and Protein Supplementation
OTHERControl
control group, no intervention, maintenance of physical activity
Sponsors
Klinikum Nürnberg
University of Erlangen-Nürnberg Medical School
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
MALE
Age
30 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* males * untrained (\< 2 h exercise/week, \< 1 h resistance exercise/week) * 30-50 years old
Exclusion criteria
* medication/diseases affecting intervention or study endpoints * history of intense resistance exercise (\> 3 h/week during the last decade) * very low physical capacity (\< 100 Watt at ergometry) * more than 2 weeks of absence during the interventional period * contraindication related to MRI-assessment (i.e. magnetizable intracorporal artefacts) * pathological changes of the heart * inflammable diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| fat free Cross Sectional Area (CSA) upper leg | change from baseline in fat free Cross Sectional Area at 5 months | fat free muscle cross sectional area of the upper leg at mid-femur via Quantitative Computed Tomography (QCT) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| CSA upper leg | change from baseline in CSA upper leg at 5 months | muscle cross sectional area of the upper leg at mid-femur via QCT |
Other
| Measure | Time frame | Description |
|---|---|---|
| intra-abdominal fat mass | change from baseline in intra-abdominal fat mass at 5 months | intra-abdominal fat mass via Magnetic Resonance Imaging (MRI) |
| maximum strength leg press | change from baseline in maximum strength leg press at 5 months | Maximum dynamic strength of the leg extensors/-flexors |
| metabolic syndrome score | change from baseline in metabolic syndrome score at 5 months | Metabolic Syndrome Score according to Johnson et al. |
| myocardial mass/enddiastolic volume | change from baseline in myocardial mass/enddiastolic volume at 5 months | — |
Countries
Germany
Outcome results
None listed