Crohn's Disease
Conditions
Keywords
Crohn's disease, endothelial progenitor cells, probiotic
Brief summary
Inflammatory Bowel Disease (IBD) is an immune mediated chronic intestinal condition. It includes ulcerative colitis (UC) and Crohn's disease(CD). probiotics have been shown to be effective in varried clinical conditions ranging fron infantile diarrhea, necrotizing enterocolitis,helicobacter pylori infections, etc.
Detailed description
This is a prospective study that will enroll 50 patients with Crohn's disease.Each patient will get the study medication for 6 weeks and will be evaluated twice- before enrollment and after 6 weeks of treatment.
Interventions
DRUGProbiotic
Clinical evaluation according to the Crohn's activity scale
DRUGPlacebo
Sponsors
The Baruch Padeh Medical Center, Poriya
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* patients with Crohns' disease who are stable or have mild acute exacerbations that do not necessitate treatment with systemic corticosteroids
Exclusion criteria
* pregnant women, under 18 years or over 60 years, * patients with known ulcerative colitis, * patients with any cancer, * patients with heart failure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| endothelial stem cells | one year | to study the ability to create endothelial progenitor stem cells following probiotic management compared to placebo group |
Countries
Israel
Outcome results
None listed