Female Urogenital Diseases
Conditions
Brief summary
The purpose of this study is to determine whether laser-assisted zona thinning improve the implantation rate of the women of advanced age in the first IVF/ICSI cycles
Detailed description
Registry procedures： 1. It's required to sign an informed consent form prior to the recruitment of all patients. 2. Data collection and entry need double check and supervision. The outcome measures: the implantation rate per embryo transfer miscarriage live birth
Interventions
DEVICEZILOS-TK IVOS Analyzer
The subjects are going to participate the treatment of assisted hatching in vitro fertilization by Zona Infrared Laser Optical System (ZILOS-TK,Hamilton Thorne Biosciences,USA)
Sponsors
Shanxi Provincial Maternity and Children's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
35 Years to 46 Years
Healthy volunteers
No
Inclusion criteria
* Age: 35y ≤age≤46y * Basal FSH value: FSH≤10IU/L * Day-3 embryos transferred in the fresh IVF/ICSI cycles * the number of embryos available to be transferred on Day-3: ≥one embryo
Exclusion criteria
* cycles with thawed/warmed embryos biopsied for PGD/PGS. * cycles with oocyte donation transfer. * the maximum number of previous unsuccessful IVF attempts: ≥ 3 cycles(transfer cycles) * any cycles with the risk of OHSS, fluid in the uterine cavity, abnormal endometrium, uterine abnormalities,pelvic inflammation, and other acute maternal problems. * One or both spouses have an abnormal karyotype (including polymorphism)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The implantation rate | 30 days | the implantation rate per embryo in first fresh embryos transfer cycles |
Secondary
| Measure | Time frame |
|---|---|
| The miscarriage | 24 weeks |
Countries
China
Contacts
Primary ContactJuanzi Shi, Doctor
Outcome results
None listed