Chronic Thrombocytopenia
Conditions
Keywords
Chronic ITP, Cerebral dysfunction
Brief summary
Intracranial hemorrhage despite being rare, several chronic ITP patients experience moderate to severe behavioral problems including learning difficulties, memory affection .These changes could be due to the presence of minute capillary dysfunction
Detailed description
* First identify the presence of cognitive, behavioral and/or minimal neurological deficit in patients with chronic ITP and correlate these changes with radiological evidence of minimal CNS bleeding. * Second investigate the correlation between these behavioral and/or minimal neurological deficits and duration, site and severity of bleeding (a total of 200 patient of persistently low platelet count \< 20x 10 9 for at least more than one month duration). * The aim is to assess the behavioral changes in chronic ITP patients, and to assess the possible relation of such changes to duration and recurrence of very low platelet count as well as pattern of bleeding excluding frank intracranial hemorrhage.
Interventions
OTHERIQ assessment and visual- motor assessment
Psychological examination and evaluation for both groups to diagnose those with behavioral and /or cognitive dysfunction.
OTHEREEG,brain imaging
For patients with cognitive or behavioral deficit, MRI brain and quantitative EEG will be done to identify any CNS abnormality.
Sponsors
Ain Shams University
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
4 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
1. Chronic ITP patients with persistent platelet count \< 20 x 109/L for a period more than one month. 2. Chronic ITP with more than one attack of wet purpura and OR internal bleeding.
Exclusion criteria
1. Patients' with platelet count persistently more than 40 x 109/L. 2. Past history of intracranial hemorrhage. 3. Past history of known neurological or psychological deficit diagnosed before onset of ITP diagnosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| cognitive, behavioral and/or minimal neurological deficit in patients with chronic ITP | 6 month | cognitive, behavioral and/or minimal neurological deficit in patients with chronic ITP and correlate these changes with radiological evidence of minimal CNS bleeding. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| duration, site and severity of bleeding effect of duration, site and severity of bleeding | 6 months | behavioral and/or minimal neurological deficits and duration, site and severity of bleeding |
Countries
Egypt
Contacts
Primary Contactyasmine I Elhenawy, lecturer
Outcome results
None listed