Taste Acuity and Caloric Intake After Acute Morphine Administration

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01763697

Enrollment

Registered

2013-01-09

Start date

2013-03-31

Completion date

2014-05-31

Last updated

2014-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Feeding Behavior, Taste Salty, Taste Sweet

Keywords

Taste acuity, Feeding behavior, opioid, Quantitative assessment

Brief summary

This study will investigate the effects of acute morphine administration on taste acuity and how much a person eats. It is hypothesized that there will be a dose dependent decrease in taste acuity and dose dependent increase in food intake associated with acute morphine administration. Knowledge from this study will impact the future of feeding behavior and obesity research in the general population. Results will also promote exploration of the long-term effect of opioid abuse on taste acuity and feeding behavior in substance abusing populations.

Interventions

BEHAVIORALtaste acuity assessment

Quantitative measurement of for tasting detection and recognition thresholds, magnitude of perception and hedonic response.

BEHAVIORALRecorded meal

Study design

Allocation

RANDOMIZED

Intervention model

FACTORIAL

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy adult male and female volunteers * Ages of 18 to 65

Exclusion criteria

* History of drug dependence (including opioid use disorders) * History of taste dysfunction * Significant medical or Axis I psychiatric disorder * Any trauma or surgical procedures to the head or neck region * Medication or illicit drug more than 4 out of the last 30 days. * Pregnancy * Abnormal electrocardiogram findings * Negative rating of greater than 40% of the foods available for consumption

Design outcomes

Primary

Measure	Time frame	Description
Taste	3 hours after dose administration	The primary outcome variable will be the taste acuity profile, which includes the taste detection threshold, recognition threshold, magnitude estimation, and hedonic response.

Secondary

Measure	Time frame	Description
Calories	6 hours after dose administration	The secondary outcome measure will be the amount of calories consumed over a 2 hours period following the drug administration.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026