Body Mass Index Quantitative Trait Locus 8 Disorder, Tangier Disease
Conditions
Keywords
body weight, Low-density-lipoprotein-type
Brief summary
The investigators aimed to determine the effects of HP diet on CVD risk factors and hs-CRP among overweight and obese women.
Detailed description
Background: Studies regarding the effects of high protein (HP) diet on cardiovascular (CVD) risk factors have reported contradictory results. Objective: In present study, we aimed to determine the effects of HP diet on CVD risk factors and hs-CRP among overweight and obese women. Design: In this randomized controlled trial, we recruited 60 overweight and obese women, aged 20-65 years into HP or control energy restricted diets for three months (protein, carbohydrate, fat: 25%, 45%, 30% vs. 15%, 55%, 30%, respectively). Total protein amount, divided to animal and plant sources in 50%-50% and animal sources distributed (half/half) between meats and dairy products. Fasting blood samples, hs-CRP, lipid profile, systolic and diastolic blood pressure and anthropometric measurements were measured based on the standard guidelines.
Interventions
OTHERnutrition intervention
high protein diet
Sponsors
Isfahan University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* women aged between 20-65 years * BMI \> 25 kg/m2 * were no smoker * no history of renal, liver, metabolic diseases or type 1 or 2 diabetes
Exclusion criteria
* had gastrointestinal, respiratory, cardiovascular, metabolic, liver and renal -diseases * had macroalbuminuria * were pregnancy or lactating
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the amount of weight reduction in two dietary groups | 3 months | weight reduction (kg) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| HDL-C (mg/dl) | 3 months | — |
| total cholesterol (mg/dl) | 3 months | — |
| LDL-C (mg/dl | 3 months | measurement of LDL-C (mg/dl), HDL-C (mg/dl), total cholesterol (mg/dl), fasting blood glucose (mg/dl), systolic and diastolic blood pressure (mmHg), c reactive protein by the measurement of blood samples. |
| blood pressure (mmHg) | 3 months | — |
| C-reactive protein (mc/dl) | 3 months | — |
| fasting blood glucose(mg/dl) | 3 months | — |
Outcome results
None listed