Use of Oxygen Nebulizer for Preventing Post-operative Sore Throat

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01763177

Acronym

POST

Enrollment

1036

Registered

2013-01-08

Start date

2013-01-31

Completion date

2015-06-30

Last updated

2015-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain, Postoperative

Keywords

nebulizer, oxygen, post-operative sore throat

Brief summary

Rationale: Delivery dry gas during anesthesia is associated with post-operative sore throat (POST). Oxygen nebulizer therapy increases humidity to the airway, especially post-extubation. Objective: To investigate the effect and complications of oxygen nebulizer therapy on POST.

Interventions

OTHEROxygen

Oxygen mask 40% 8 LPM for 30 minutes

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Age 18-75 years * Pre-operative Hb \>10 g% or Hct \> 30% * American Society of Anesthesiologist (ASA) class I-III * Elective surgery * General anesthesia with oroendotracheal tube using Macintosh laryngoscope * Not exposed to intraoperative nitrous oxide * Oxygen saturation at room air \> 95% before induction and at arrival the PACU

Exclusion criteria

* Cases needing ICU admission immediately post-operative * Conditioning requiring post-operative oxygen therapy e.g. heart disease, pregnancy, morbid obesity, cardiac and thoracic surgery * Patients' conditioning affecting to complication of nebulizer oxygen therapy e.g. pulmonary disease, bleomycin treatment * Patient's conditioning affecting POST assessment e.g. pre-operative using ventilator, recent upper respiratory tract infection (URI), recent lower respiratory tract infection and history of difficult airway * Surgical conditioning affecting POST e.g. airway surgery, oral surgery, esophageal and neck surgery

Design outcomes

Primary

Measure	Time frame	Description
The effect of oxygen nebulizer therapy on post-operative sore throat	at post-anesthetic care unit and 24-h post-operative	Assess POST using scoring system and discomfort by interview. Sore throat scoring system is divided into 4 scores 0 means no sore throat 1. means minimal sore throat (less severe than cold) 2. means moderate sore throat (similar to cold) 3. means severe sore throat (more severe than cold)

Secondary

Measure	Time frame
To evaluate the adverse events (pulmonary complications, wound infection, and mortality) of post-operative complications related to oxygen therapy	24-h post-op and 30-d mortality

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026