Khalifa Acute Effects

Interdisciplinary Evaluation of Acute Effects From Khalifa's Therapy at Patients With Fully Ruptured Anterior Cruciate Ligament (ACL).

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01762371

Enrollment

Registered

2013-01-07

Start date

2012-12-31

Completion date

2014-02-28

Last updated

2015-05-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Totally Ruptured Anterior Cruciate Ligament in the Knee

Keywords

ACL, Knee, Ligament, Cruciate, Anterior

Brief summary

The primary hypothesis is that Khalifa's therapy has different acute effects in various organ systems i.e. proprioceptive, neuro-muscular, endogenous dopamine system, etc. These effects might indicate the pathway of the therapy.

Detailed description

According to our previous study that evaluated the efficacy of Khalifa's therapy the investigators have seen that the therapy has acute effects which resulted in better knee function and later even in better healing of the ACL injury. This study should clear exactly which effects and pathways are involved in the therapy from multiple (interdisciplinary) point of views. Therefore the investigators will measure parameters that might be associated with this special technique directly before and after the therapy.

Interventions

OTHERKhalifa Therapy

One hour of Khalifa's therapy which is specially applied pressure to the skin.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

18 Years to 49 Years

Healthy volunteers

Inclusion criteria

* totally ruptured ACL - MRI verified, 2 weeks old as a maximum * knee function: Any functional inhibition (stretching, bending or load) * BMI: 18-25 * athletically active

Exclusion criteria

* any surgical procedures at the injured knee at any previous time * any acute surgical indication * diabetes mellitus and/or high blood pressure * any permanent drug treatment

Design outcomes

Primary

Measure	Time frame	Description
Blood	1 hour	Catecholamines endorphins standard blood parameters
Laser Doppler-Flow	1 hour	Perfusion
NIRS	1 hour	Near infrared spectroscopy, Oxygen saturation
IR Thermography	1 hour	Infrared thermography, temperature
QST	1 hour	Quantitative sensoric testing, pain
HRV	1 hour	Heart rate variability, sympathicus/parasympathicus activation
EEG	1 hour	Electroencephalogram, brain waves
Knee function	1 hour	IKDC Score KT-1000 test Clinical / physical examination
SportsScience	2 hours	Posturomed Motion capture proprioception muscle power range of motion

Secondary

Measure	Time frame	Description
Questionnaire	1 hour	Different questions about pain, lifestyle, subjective parameters

Countries

Austria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026