Efficacy of Diclofenac on Pain During Endometrial Sampling

Efficacy for Acute Pain Alleviation of 50 mg Diclofenac 1 Hour Prior to Endometrial Sampling in Cases of Abnormal Uterine Bleeding

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01762306

Enrollment

Registered

2013-01-07

Start date

2012-11-30

Completion date

2013-06-30

Last updated

2013-01-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abnormal Uterine Bleeding Unrelated to Menstrual Cycle

Brief summary

Abnormal uterine bleeding is common in Thai women. Traditionally, because of a larger number of patients, the diagnosis of its cause is performed via fractional curettage under local anesthesia such as paracervical nerve block or intravenous meperidine. Pain is one of a common adverse effect of this procedure and this topic should be concerned by a responsible doctor. NSAIDs, Diclofenac Potassium in this study, is known as a drug which is effective for pain control and is as effective as coxib in acute pain management. Because of its cost, easy accessible and easy administration, Diclofenac Potassium was selected to be used in this study. Its onset of action is about 1 hour and only one dose of this drug do not cause any serious side effects. The hypothesis of this study is that Diclofenac Potassium has an additional effectiveness for acute pain control in patients undergoing fractional curettage under paracervical nerve block due to abnormal uterine bleeding Double blind randomised controlled trial was performed in this study with 45 patients included in each group.

Interventions

DRUGDiclofenac Potassium

DRUGFolic Acid

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

35 Years to No maximum

Healthy volunteers

Inclusion criteria

* Thai women at the age over 35 years old * Presenting with abnormal uterine bleeding and have a plan of performing fractional curettage

Exclusion criteria

* uterine anomalies * pregnancy * Pelvic inflammatory disease * Uncontrolled medical conditions * Known cases of gynecological diseases such as gynecological malignancy, abnormal pap smear * NSAIDs allergy * contraindicate to NSAIDs use

Design outcomes

Primary

Measure	Time frame	Description
Effectiveness of Diclofenac Potassium for additional acute pain control in patient undergoing fractional curettage under paracervical block due to abnormal uterine bleeding	1 Year	Effectiveness of oral 50 mg Diclofenac Potassium was measured by pain score using visual dialogue scale during operation and 30, 60, 90 and 120 minutes after procedure.

Countries

Thailand

Contacts

Primary ContactKorakot Sirimai, Dr.

ksirimai@hotmail.com(66)81-6140655

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026