Hyperbilirubinemia, Neonatal
Conditions
Keywords
Hyperbilirubinemia, Neonatal, Incidence, Risk factors
Brief summary
Thirteen hospitals in China will participate in the study, which aims to provide data on serum bilirubin levels in the first 168 hr after birth in term and late-preterm neonates, and estimate the incidence of severe neonatal hyperbilirubinemia and the underlying causes. We hypothesize that the study can be value in identifying and implementing strategies for risk reduction.
Detailed description
Neonatal hyperbilirubinemia resulting in clinical jaundice is a common problem among infants, particularly during the first weeks of life. Information about the incidence and risk factors of neonatal jaundice is not available from China where is one of the highest countries of the incidence of severe neonatal hyperbilirubinemia.
Interventions
PROCEDUREPhototherapy
The decision to use phototherapy conformed to the hour-specific threshold value for phototherapy presented by the American Academy of Pediatrics guidelines and was not at the discretion of the investigators.
Sponsors
Children's Hospital of Fudan University
Nanjing Maternity and Child Health Care Hospital
Jinlin Provincial Maternal and Child Health Hospital
Peking University Third Hospital
Inner Mongolia Maternal and Child Health Care Hospital
Shanxi Provincial Maternity and Children's Hospital
Obstetrics & Gynecology Hospital of Fudan University
Guangdong Women and Children Hospital
Guangxi Maternal and Child Health Hospital
The First Affiliated Hospital of Zhengzhou University
First Affiliated Hospital of Xinjiang Medical University
First Affiliated Hospital of Harbin Medical University
Sichuan Provincial People's Hospital
Guiyang Maternity and Child Health Care Hospital
Nanjing Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Days to 28 Days
Healthy volunteers
Yes
Inclusion criteria
Term or late-preterm newborn infants with GAs of ≥35 weeks and birth weights of ≥2,000 g were included.
Exclusion criteria
All sick newborn infants who were admitted to the intensive care unit.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The incidence of severe neonatal hyperbilirubinemia | At the 28 days after birth | Significant hyperbilirubinemia was defined as any TSB level that exceeded the hour-specific threshold value for phototherapy, according to the guidelines presented by the American Academy of Pediatrics. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with risk factors associated with severe neonatal hyperbilirubinemia | At the 28 days after birth | The risk factors recognized to be associated with significant hyperbilirubinemia in newborns have included gestational age, weight for Gestational Age, delivery mode, gender, previous infant had phototherapy, bruising/cephalahematoma, feeding mode, excessive body weight loss, and early discharge, et al. |
Countries
China
Outcome results
None listed