Abortion, Spontaneous, Endometritis, Infertility
Conditions
Keywords
In vitro fertilization, Hysteroscopy, Endometrial biopsy
Brief summary
Chronic endometritis is a persistent inflammation of the endometrium. Chronic endometritis is asymptomatic or little symptomatic. Sometimes, patient with chronic endometritis can have genital bleeding, pelvic chronic pain, pain during sexual relations, persistent vaginal white loosing. The hysteroscopy can detect the presence or absence of chronic endometritis. Some studies showed that the endometritis could have an impact on the embryo implantation and could explain recurrent miscarriages or repeated embryo implantation failures. The goal of this study is to evaluate the frequency of the chronic endometritis in patients with recurrent miscarriages or repeated embryo implantation failures
Interventions
None listed
Sponsors
Clinique Ovo
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
Group repeated miscarriages * Women aged 18 to 43 years * ≥ 2 miscarriages before 14 weeks of gestation * Genetic (karyotype x2), thrombophilic and endocrine assessment should be completed Group of implantation failure in In-vitro fertilization * Women aged 18 to 45 years * Absence of pregnancy after 3 good quality embryos transferred in women under 35 years and 4 embryos in the 35 years and over.
Exclusion criteria
* Positive pregnancy test * Unexplained bleeding * Incomplete miscarriage assessment * Uterine malformation * Antibiotic treatment during or within one month prior to the biopsy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of chronic endometritis | 1 day |
Secondary
| Measure | Time frame |
|---|---|
| Pregnancy rate | 1 year |
Countries
Canada
Outcome results
None listed