Healthy
Conditions
Keywords
homocysteine-vitamin B12-fish oil-ferritin
Brief summary
Vitamin B12and n-3 polyunsaturated fatty acids (PUFA) decrease blood homocysteine (Hcy) concentration. However, the combined effect of these nutrients on Hcy and ferritin, and C-reactive protein is limited and inconclusive. The objective was to examine the synergistic effect of vitamin B12 in combination of n-3 PUFA on plasma Hcy, ferritin, and other biochemical markers. In a randomized controlled trial, thirty eligible subjects were randomly divided into three groups, and assigned to receive 1000 μg of vitamin B12, 2g fish oil, or 1000 μg vitamin B12 and 2g fish oil respectively for 8 weeks. Plasma phospholipid (PL) fatty acids and biochemical markers were determined. we hypothesize that combination of vitamin B12 and fish oil have synergistic effect on lowering plasma concentrations of Hcy and ferritin.
Interventions
DIETARY_SUPPLEMENTFish oil
DIETARY_SUPPLEMENTvitaminB12
Sponsors
Zhejiang University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
20 Years to 28 Years
Healthy volunteers
Yes
Inclusion criteria
* reliability, regular eating habits, normal weight, nondrinking, and nonsmoking status
Exclusion criteria
* None of the selected subjects used any vitamins or dietary supplements and was taking no medication for at least 8 weeks before the start of and during the entire experimental period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| homocysteine,umol/L | 10 weeks |
Countries
China
Outcome results
None listed