Postural Tachycardia Syndrome
Conditions
Brief summary
The purpose of this study is to determine whether Ivabradine is an effective treatment for postural tachycardia syndrome.
Interventions
DRUGivabradine
Sponsors
Tel-Aviv Sourasky Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* Patients diagnosed with POTS by the following criteria: 1. The presence of characteristic orthostatic symptoms of the POTS for at least six months. 2. An increase in the heart rate of at least 30 beats per minute (without concomitant significant decrease in blood pressure of more than 20/10 mmHg) within 10 minutes after assuming a standing position (or during tilt test) on at least 3 separate occasions. 3. No other concomitant diseases that could explain the symptoms of POTS.
Exclusion criteria
<!-- --> 1. History of systemic illness capable of affecting of affecting autonomic function (eg, diabetes mellitus, SLE). 2. History of cardiovascular disease. 3. History of smoking, drug or alcohol abuse. 4. Pregnancy, and also uncontrolled thyroid or adrenal disorders. 5. Using any drug metabolized by cytochrome P450 3A4 enzyme during the last 72 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the change in heart rate after the administration of Ivabradine | 60 minutes , during the whole trial |
| the change in blood pressure after the administration of Ivabradine | 60 minutes |
Outcome results
None listed