Bilateral Dual Transversus Abdominis Plane Block for Robotic Assisted Laparoscopic Surgery

A Randomised, Double-blind Study to Evaluate the Effect of Bilateral Dual Transversus Abdominis Plane Block on Postoperative Pain and Plasma Concentration of Ropivacaine After Robotic Assisted Laparoscopic Surgery

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01760161

Enrollment

Registered

2013-01-04

Start date

2014-04-30

Completion date

2016-02-29

Last updated

2015-05-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bilateral Dual Transversus Abdominis Plane Block, Pain Treatment, Robotic Assisted Laparoscopic Surgery

Keywords

postoperative pain, opioid consumption, termanalgesia, plasmaropivacain level

Brief summary

To evaluate the effects of bilateral dual transversus abdominis plane block on postoperative pain after robotic assited laparoskopic surgery and measure the plasma-level of ropivacain after the bilateral dual transversus abdominis plane block.

Detailed description

After randomisation patients for robotic assisted laparoscopic surgery will receive bilateral dual transversus abdominis plane block containing either ropivacain or isotonic potassium chloride. The investigators will record pain-score, opioid-consumption and sensibility on the abdominal wall in the postoperative periode. Also a blood sample will be taken at 15, 30, 60, 120 and 240 minutes after the block in order to measure the plasma-level of ropivacain after bilateral dual transversus abdominis plane block. The investigators assume that there will be significant effect on postoperative pain and that the level of plasma-ropivacain will be acceptable.

Interventions

DRUGRopivacaine

Ropicacain 3,75 mg/ml 15 ml x 4 when placing the Bilateral Dual Transverus Abdominis Plane block

DRUGIsotonic potassium chloride

Isotonic potassium chloride 15 ml x 4 when placing the bilateral dual transverus abdominis plane block.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* patients scheduled for robotic assisted laparoscopis surgery * acceptance to participate

Exclusion criteria

* allergies to local analgetics * daily use of strong opioids

Design outcomes

Primary

Measure	Time frame
Pain-score on numerical rating scale	4 hours after surgery

Secondary

Measure	Time frame
Administration of opioids	The first 24 hours after surgery.
Pain-score on numerical rating scale	8 hours after surgery

Other

Measure	Time frame
Thermoanalgesia at dermatome-level th6-th12	1 hour after bilateral dual transversus abdominis plane block
Plasma-ropivacain level	15, 30, 60, 120 and 240 mins after the block

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026