Anesthesia
Conditions
Keywords
electroconvulsive therapy,sevoflurane,propofol,remifentanil
Brief summary
To compare the effectiveness of three different anesthetic regimens (propofol, remifentanil-propofol and sevoflurane in ECT.
Detailed description
The purpose of this study is to compare the effectiveness of three different anesthetic regimens (propofol, remifentanil-propofol and sevoflurane) with respect to seizure duration, postictal suppression index, early and midictal amplitude, hemodynamic variables and recovery profiles in ECT.
Interventions
DRUGPropofol
1 mg/kg propofol IV (over 15 sec) during anesthesia induction
1 µg/kg IV (over 60 sec)remifentanil and 0.5 mg/kg propofol IV (over 15 sec)during anesthesia induction
DRUGSevoflurane
Sevoflurane was started at 6% for induction and continued at 1% until the electrical stimulus was delivered
Sponsors
Inonu University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Upremedicated ASA I-II (American Society of Anesthesiologists's physical status) patients, * Patients scheduled for six ECT sessions for a variety of psychiatric conditions (major depression, schizophrenia)
Exclusion criteria
* Involuntary patient status * Patients with known or self-declared needle or mask phobia * Pregnancy * Asthma * Cerebrovascular disease, * History of myocardial infarction in the previous 6 months, * Atrial fibrillation or flutter,heart block, * A known or family history of reactions to the study drugs.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Seizure duration | The patients were observed about seizure up to ten minutes after electrical stimulation | After anesthesia induction patients were administered electrical stimulation and seizure duration were measured. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| postictal suppression index | completing seizure in one hour | After anesthesia induction, patients were administered electrical stimulation. Then, postictal suppression index, a parameter that shows seizure quality, was determined from seizure records. |
| Recovery parameters (spontaneous breathing, eye opening, and obeying of verbal commands) | after seizure in one hour in operation room. | The time from the end of succinylcholine administration to the recovery of spontaneous breathing, eye opening, and obeying of verbal commands were recorded. |
| Hemodynamic variables | Before administration of the study medications (t0), and at 1 (t1), 3 (t2), and 10 (t3) minutes after the seizure ended. | During perioperative period: Before administration of the study medications (t0), and at 1 (t1), 3 (t2), and 10 (t3) minutes after the seizure ended. |
Countries
Turkey (Türkiye)
Outcome results
None listed