Respiratory Distress Syndrome
Conditions
Brief summary
Heliox can lower respiratory resistance, improve the oxygenation, reduce respiratory distress and lung injury caused by mechanical ventilation.
Detailed description
Heliox can improve the oxygenation, reduce respiratory distress and lung injury caused by mechanical ventilation. Heliox has not been widely used. More studies on the effects and safety of Heliox in addition to NIPPV and mechanical ventilation should be tried.
Interventions
OTHERheliox
heliox or oxygen is used in the two groups respectively
Sponsors
Third Military Medical University
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
28 Weeks to 37 Weeks
Healthy volunteers
No
Inclusion criteria
* Gestational age more than 28 weeks and less than 32 weeks * Diagnosed as respiratory distress syndrome * Need to use NIPPV ventilation * No congenital diseases or hereditary diseases * With an informed consent form
Exclusion criteria
* With congenital diseases or hereditary diseases * Intubated in the delivery room * Need surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| length of ventilation and risk of mechanical ventilation | participants will be followed for the duration of hospital stay, an expected average of 2 weeks | The primary outcome is the length of ventilation and risk of mechanical ventilation of participants. |
Secondary
| Measure | Time frame |
|---|---|
| Transcutaneous blood gas analysis，ventilator parameters and lung inflammation cytokines | participants will be followed for the duration of hospital stay, an expected average of 2 weeks |
Countries
China
Outcome results
None listed