China Action on Spine and Hip Status

Multi Center Survey on Spine and Hip Status in Chinese Population Using Quantitative Computed Tomography (QCT)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01758770

Acronym

CASH

Enrollment

3457

Registered

2013-01-01

Start date

2012-10-31

Completion date

2017-07-26

Last updated

2018-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Steatosis, Metabolic Syndrome, Obesity, Osteoporosis

Keywords

osteoporosis, osteoarthritis, bone mineral density, computed xray tomography, liver steatosis, obesity

Brief summary

1. To determine the prevalences of osteoporotic fracture in elderly Chinese population. 2. To determine the prevalences of osteoporosis in elderly Chinese population using QCT BMD measurement. 3. To investigate the difference in the prevalences of osteoporosis between cities and urban-rural area in China. 4. To investigate the association of body composition with osteoporosis 5. To investigate the prevalence of liver steatosis in China 6. To investigate the application of QCT fat measurement

Detailed description

Osteoporosis and osteoarthritis (OA) both are very common in elderly population,it is particular important for China with a huge aging population in the coming years.Bone mineral density measured by quantitative computed tomography (QCT) or dual energy X-ray absorptiometry (DXA) is the surrogate for bone health status and diagnosis of osteoporosis and OA. In this study we utilize the large-scale population based epidemiology study (PURE) population,spine and hip QCT and/or DXA will be obtained for the subject to investigate the prevalence of osteoporosis and osteoarthritis in elderly Chinese population. We also study the relation between bone mineral density with osteoporotic fracture and OA More than 3000 subjects selected from the PURE study participants in Beijing and other centers in China will be recruited to this study. More precisely, the subjects are consisted of the females over 55 years and males over 60 years old, along with the 20% randomly selected PURE participants for blood sampling. Beijing ji shui tan hospital will be the coordinate center for the whole study, Beijing shi jing shan hospital, Beijing shun yi traditional medicine hospital and Taiyuan central hospital of shanxi will participate, other centers may be added late. Bone mineral density of spine and hip will be measured with QCT and/or DXA. Quantitative computed tomography QCT pro (Mindways software, inc. USA) will be used for all QCT measurement, the CT scanner will be the clinical CT scanner of the local participated center. Quality control and monitoring will be conducted by Beijing ji shui tan hospital, as well as the centralised image interpretation. Therefore, this study is designed to provide the current and reliable prevalence of osteoporotic fracture, osteoporosis, OA in elderly Chinese population using QCT and/or DXA. The performance of QCT and DXA in the diagnosis of osteoporosis , as well as the association of body composition with osteoporosis will be assessed.

Interventions

None listed

Study design

Observational model

FAMILY_BASED

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

29 Years to 90 Years

Healthy volunteers

Yes

Inclusion criteria

1. Inclusion Criteria: 1. Participants of the PURE study in China (PURE China study) 2. be willing to and be able to join in the study and signed Informed consent 2.

Exclusion criteria

1. Pregnant 2. Spine and both hip implants

Design outcomes

Primary

Measure	Time frame	Description
Osteoporotic fractures	5 years	The spine osteoporotic fractures assessed on the lateral spine image of QCT exam
Bone mineral density (BMD) of spine and hip	5 years	BMD measurement at the spine by QCT and hip
liver steatosis	5 years	The liver steatosis assessed by QCT

Secondary

Measure	Time frame	Description
Metabolic syndrome	5 years	Diagnosis of metabolic syndrome and visceral fat
visceral fat measurement by QCT	5 years	visceral fat measurement and distribution assessed by QCT at the abdomen and hip
Osteoarthritis of spine and hip	5 years	OA assessment at spine and hip by CT images

Countries

China

Outcome results