Carbon Monoxide Poisoning
Conditions
Keywords
CO poisoning
Brief summary
The purpose of this biorepository is to collect blood from patients at the time of CO poisoning and at follow-up visits months to years later. These samples can be used in the future to learn more about how CO damages the heart and brain and whether blood tests could predict which patients will have problems after CO poisoning.
Detailed description
The investigators propose to establish a biorepository for storage of serum, plasma, and DNA collected from patients with carbon monoxide (CO) poisoning. Participants will also be evaluated for clinical outcome. The biorepository will include serum and plasma from CO-poisoned patients drawn at the time of injury as well as from blood drawn at clinical follow-up visits. The biorepository will also bank DNA from these participants. These specimens can be analyzed in the future to elucidate potential inflammatory and immunological mechanisms that cause brain and heart damage and identify possible biological and genetic predictors of poor outcome.
Interventions
There is no study-related intervention.
Sponsors
Intermountain Health Care, Inc.
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Symptomatic carbon monoxide poisoning (headache, nausea, vomiting, dizziness, fatigue, muscle aches, slowed mentation, confusion, loss of consciousness, etc.). 2. Documented exposure to carbon monoxide and no other reasonable explanation for their signs and symptoms.
Exclusion criteria
1. Pregnancy 2. Age \< 18 years 3. Unable to obtain informed consent 4. Subjects who, in the opinion of the investigator, are unable to comply with the requirements of the study or are unsuitable for any reason. The investigator and the Sponsor, prior to enrolling the subject on a case-by-case basis, must approve and document any waiver of these inclusion and
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Biorepository for serum and plasma | Within 24 hours of CO Poisoning | Serum and plasma from blood collected within 24 hours of acute CO poisoning |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Serum and plasma (sub-acute) | 4 weeks to 4 months after CO poisoning | Serum and plasma collected 4 weeks to 4 months after poisoning |
| DNA Sequestration | 24 hours to 12 months after CO poisoning | DNA sequestered from blood drawn up to 1 year from CO poisoning |
| Serum and plasma (long-term) | 4 months to 12 months after CO poisoning | Serum and plasma collected 4 months to 12 months after poisoning |
Countries
United States
Outcome results
None listed