Hypertension
Conditions
Keywords
Hypertension, Health Care Cost, Monthly health care cost
Brief summary
This is a retrospective data analysis of patients with high blood pressure (hypertension) who took metoprolol for a minimum of 6 months who then switched to taking nebivolol for a minimum of 6 month to treat hypertension. These patients will be identified from a large medical claims database. This study tests the hypothesis (alternative, higher or lower) that average patient monthly health care administrative cost changes after switching from metoprolol to nebivolol.
Interventions
DRUGMetoprolol
Metoprolol, oral administration
DRUGNebivolol
Nebivolol, oral administration
Sponsors
Forest Laboratories
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Be at least 18 years old at initiation of metoprolol (or first date on metoprolol treatment between 2007 and 2011) * Had one or more inpatient or outpatient claims with a primary or non-primary diagnosis of hypertension (ICD-9-CM 401.xx-405.xx) * Received nebivolol treatment continuously (defined as supply gap \<30 days) for at least 6 months after initiation * Received metoprolol treatment continuously for at least 6 months prior to switching to (initiation of) nebivolol (defined as metoprolol was discontinued whereas a prescription for nebivolol was filled) * Had at least 12 months of continuous enrollment (as verified using enrollment file): 6 month prior to nebivolol initiation and 6 months following nebivolol initiation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Patient monthly health care cost | 6 months | The average per patient monthly health care cost for the pre-specified hypertensive target study population during the 6 months before and after switching from metoprolol to nebivolol |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of monthly out-patient visits | 6 months | Estimate the average per patient monthly number of out-patient visits for the pre-specified hypertensive target study population during the 6 months before and after switching from metoprolol to nebivolol. |
| Monthly Emergency Room visits per patient | 6 months | Estimate of the average monthly number of Emergency Room (ER) visits per patient for the pre-specified hypertensive target study population during the 6 months before and after switching from metoprolol to nebivolol. |
| Monthly hospitalizations per patient | 6 months | Estimate of the average monthly number of hospitalizations per patient for the pre-specified hypertensive target study population during the 6 months before and after switching from metoprolol to nebivolol. |
Countries
United States
Outcome results
None listed