Idiopathic Hypogonadotropic Hypogonadism
Conditions
Keywords
hypogonadism, Retinol binding globulin 4, Testosterone treatment
Brief summary
The aim of the present study was to demonstrate the RBP4 levels, association of RBP4 with insulin resistance and influence of testosterone treatment on this cytokine in patients with idiopathic hypogonadotropic hypogonadism.
Interventions
DRUGSustanon 250 mg ampule (Testosterone esters)
Drug used for treatment of hypogonadism
Sponsors
Gulhane School of Medicine
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
19 Years to 26 Years
Healthy volunteers
Yes
Inclusion criteria
decreased serum testosterone concentration below the normal range (serum T \< 300ng/dL), FSH and LH levels within or below the normal range, absence of a pituitary or hypothalamic mass lesions on MRI, presence of gonadotropin response to repetitive doses of GnRH, normal smell test and normal karyotypes
Exclusion criteria
previous androgen treatment, history of smoking, presence of bilateral anorchia, intellectual deficiency, diabetes mellitus, arterial hypertension or dyslipoproteinemia, medication of any kind and drug abuse. Because of possible confounding effects, patients with other hormone deficiencies were excluded. \-
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Retinol binding protein 4, hs-CRP levels in patients with idiopathic hypogonadotrophic hypogonadism | 2008-2012 |
Secondary
| Measure | Time frame |
|---|---|
| Effect of testosterone treatment on retinol binding globulin 4 and hs-CRP levels in patients with hypogodotrophic hypogonadism | 2008-2012 |
Countries
Turkey (Türkiye)
Outcome results
None listed