The Effect of Stevia Rebaudiana Extracts on Different Variables Related to Caries: an in Vitro and in Vivo Evaluation.

A Comparative Clinical Evaluation of the Effect of Stevia Rebaudiana Extracts and Sucrose on Dental Plaque pH (Stephan Curve Trend) Using a Microtouch Electrode in Healthy Volunteers. A Phase II Study.

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01757990

Enrollment

Registered

2012-12-31

Start date

2012-03-31

Completion date

2012-06-30

Last updated

2013-01-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental Caries

Keywords

dental caries, Stevioside, Rebaudioside, plaque pH, Streptococcus mutans

Brief summary

The aim of the present investigation was to evaluate the effect of stevioside and rebaudioside on several variables related to caries development. Two approaches were performed: an in vitro evaluation of the growth of a culture of mutans streptococci and in vivo randomized study on the effect of a single rinse containing stevioside and rebaudioside on plaque-pH.

Interventions

DIETARY_SUPPLEMENTEffect of Stevioside and Rebaudioside on plaque pH

After measuring baseline plaque pH, the subjects rinsed for 1 minute with the sucrose solution. Plaque pH was then measured at 5, 10, 15, 30, 45 and 60 min after the mouth rinse.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

20 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

good general health, normal salivary secretion rate, normal buffer capacity

Exclusion criteria

systemic diseases, salivary secretion reduction, reduced buffer capacity

Design outcomes

Primary

Measure	Time frame	Description
Plaque-pH modification	5, 10, 15, 30, 45, 60 minutes	Plaque pH was measured at baseline and 5, 10, 15, 30, 45 and 60 minutes after each mouth rinse

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026