Fluid Balance During Closure of Atrial Septal Defect

Protein Distribution and Colloid Osmotic Pressure in Children With Volume and Pressure Loading Due to Congenital Heart Defects

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01757743

Enrollment

Registered

2012-12-31

Start date

2013-02-28

Completion date

2017-01-31

Last updated

2017-04-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart Defects,Congenital, Heart Septal Defects, Atrial

Keywords

Heart Septal Defects, Atrial, Oedema formation

Brief summary

This project will evaluate fluid balance and oedema formation in children with the same congenital heart disease (Atrial Septal Defect) who will either go through heart surgery with the use of Cardio Pulmonary Bypass and hypothermia or through interventional catheterization. The investigators will measure interstitial colloid osmotic pressure, distribution of proteins and cytokines. The study hypothesis is that Oedema developed during heart surgery is caused by reduced colloid osmotic pressure gradient through the capillary membrane.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

6 Months to 10 Years

Healthy volunteers

Inclusion criteria

* The diagnosis of Atrial Septal Defect scheduled for closure * Informed consent

Exclusion criteria

* Renal failure, * liver failure, * coexisting cardiac malformations

Design outcomes

Primary

Measure	Time frame
Interstitial colloid osmotic pressure	During surgery or interventional closure

Countries

Norway

Outcome results