Evaluation of Oxygen Consumption and Energy Expenditure During Spontaneous Breathing Trial.

Evaluation of Oxygen Consumption and Energy Expenditure During Spontaneous Breathing Trial - A Randomized Crossover Controled Trial.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01757093

Enrollment

Registered

2012-12-28

Start date

2012-06-30

Completion date

2013-09-30

Last updated

2014-12-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Failure

Keywords

INDIRECT CALORIMETRY, MECHANICAL VENTILATION, WEANING VENTILATOR, AUTOMATIC TUBE COMPENSATION

Brief summary

The purpose of this study is to compare the oxygen consumption and energy expenditure during the spontaneous breathing trial.

Detailed description

Patients is going to submit to the 2 spontaneous breathing trial ( Automatic tube compensation plus continuous positive airway pressure and continuous positive airway pressure without automatic tube compensation. The oxygen consumption and energy expenditure is going to measure during the spontaneous breathing trial by indirect calorimetry.

Interventions

DEVICEAutomatic Tube Compensation plus CPAP

SPONTANEOUS BREATHING TRIAL WITH AUTOMATIC TUBE COMPENSATION plus CPAP

DEVICEContinuous Positive Airway Pressure

SPONTANEOUS BREATHING TRIAL WITH CPAP

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

SUPPORTIVE_CARE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* IMPROVEMENT OR RESOLUTION OF THE UNDERLYING CAUSE OF DISEASE * INTUBATED PATIENTS\>24h * PaO2 GREATER THAN 60 mmHg WITH FiO2 LESS THAN 40% * PEEP=5 cmH2O

Exclusion criteria

* CARDIOVASCULAR INSTABILITY * FEBRILE OR HYPOTHERMIA * CHEST DRAINAGE * RESPIRATORY RATE/TIDAL VOLUME RATIO GREATER THAN 105 * PREGNANCY * FAIL IN THE SPONTANEOUS BREATHING TRIAL * LEAKS IN THE CIRCUIT * AGITATION * NOT ACCEPT PARTICIPATE IN THE STUDY

Design outcomes

Primary

Measure	Time frame	Description
Measurement of oxygen consumption through indirect calorimetry.	The measurement is during the spontaneous breathing trial, 30 minutes.	Measurements using indirect calorimetry for determination of oxygen consumption

Secondary

Measure	Time frame	Description
Measurement of energy expenditure through indirect calorimetry	The measurement is during the spontaneous breathing trial, 30 minutes.	Measurement using indirect calorimetry for determination of energy expenditure.

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026