Diet and Disease Activity in Patients With Inflammatory Bowel Disease

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01756963

Enrollment

273

Registered

2012-12-28

Start date

2012-11-30

Completion date

2018-07-31

Last updated

2019-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammatory Bowel Disease

Brief summary

In addition to a genetic susceptibility, the immune system and the intestinal microbiota, diet is hypothesized to be an important factor in the onset and progression of Inflammatory Bowel Diseases (IBD). Further insight in factors affecting disease activity may contribute to targeted interventions improving disease burden and healthcare costs for these patients. However, well-designed studies exploring the role of diet in the development of exacerbations are hardly available. The investigators hypothesize that differences in dietary patterns affects the intestinal microbiota composition and thereby contributes to the development of exacerbations in IBD. Furthermore, a subgroup of patients suffers from malnutrition, although the exact prevalence is unknown since simple noninvasive screening tools have not been validated for IBD. The investigators hypothesize that malnutrition is frequently present in IBD patients and associated with dietary intake and disease characteristics.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* IBD patients, diagnosis based on clinical, endoscopic, histological and/or radiological criteria * participating IBD-SL cohort

Exclusion criteria

* Unable to provide informed consent

Design outcomes

Primary

Measure	Time frame
The primary aim is to study the association of dietary patterns with disease activity in a consecutive cohort of IBD outpatients	2 years

Secondary

Measure	Time frame	Description
To characterize the intestinal microbiota in IBD patients in remission developing an exacerbation during follow up	2 years	—
To investigate the stability of the intestinal microbiota in IBD patients remaining in remission during one year follow-up	2 years	—
To characterize intestinal microbiota in IBD patients with different dietary patterns	2 years	—
The study the association of disease characteristics and dietary intake with the prevalence of malnutrition in a consecutive cohort of IBD outpatients	1 year	—
To study the sensitivity and specificity of the SNAQ / MST as malnutrition screening tool in IBD outpatients based	1 year	—
To study the prevalence of malnutrition in a consecutive cohort of IBD outpatients	1 year	In a subpopulation of the present cohort (n=300) the nutritional status will be investigated

Countries

Netherlands

Outcome results