Brain Function and Perfusion in Patients With Heart Failure

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01756014

Acronym

BRAIN-HF

Enrollment

Registered

2012-12-24

Start date

2012-01-31

Completion date

Unknown

Last updated

2012-12-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral Hypoperfusion, Cognitive Impairment, Dilated Cardiomyopathy, Heart Failure, Perfusion

Brief summary

The investigators will evaluate the determinants of cerebral impairment in patients with non-ischemic heart failure compared to controls, and its relation to cognitive function. They hypothesize that patients with heart failure have impaired brain perfusion and hemodynamic factors are associated with cognitive dysfunction.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Control Group: * Healthy subject, as assessed by clinician * Age matched with patient group

Exclusion criteria

Control Group: * Age \< 18 years * Carotid artery or intracranial disease, as assessed by echo-doppler (significant stenosis \> 50%) * Unable or unwilling to undergo MRI * The presence of ferromagnetic material in or on the body, for example tattoos with ferrous ink or pacemakers or cardiac defibrillators. Also the presence of pregnancy and claustrophobia. * History of cognitive impairment * Unable to understand procedures * Unable or unwilling to provide informed consent Inclusion Criteria DCM-group: * Heart failure due to DCM * 15 patients with NYHA class II * 15 patients with NYHA class III/IV

Design outcomes

Primary

Measure	Time frame	Description
Determinants of cerebral impairment	Baseline	Determinants of cerebral impairment in patients with heart failure compared to controls, where cerebral impairment is defined as decreased cognitive function and cerebral hypoperfusion

Secondary

Measure	Time frame	Description
Relation of cognitive impairment with local perfusion	Baseline	Relation of cognitive impairment with perfusion of carotid artery territory and basilar artery territory
Relation of cognitive impairment with the severity of heart failure	Baseline	Relation of cognitive impairment with the severity of heart failure
Relation of cognitive impairment with cardiac output	Baseline	Relation of cognitive impairment with cardiac output
Prevalence of cognitive impairment	Baseline	Prevalence of cognitive impairment in patients with heart failure
Relation of cognitive impairment with the decrease in cerebral perfusion	Baseline	Relation of cognitive impairment with the decrease in cerebral perfusion
The difference of cognitive domains in above relations	Baseline	The difference of cognitive domains in above relations
Relation of cognitive impairment with the severity of congestion	Baseline	Relation of cognitive impairment with the severity of congestion

Countries

Netherlands

Contacts

Primary ContactAdriaan A Voors, MD/PhD

a.a.voors@umcg.nl+31 50 3612355

Outcome results