Light-Scattering Spectroscopy for Detection of Breast Cancer

Light-Scattering Spectroscopy for the Detection of Stage II-III Breast Cancer: A Pilot Study

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01755208

Enrollment

110

Registered

2012-12-24

Start date

2012-11-21

Completion date

2020-11-19

Last updated

2021-11-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy, no Evidence of Disease, Stage II Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer, Stage IIIC Breast Cancer

Brief summary

This pilot clinical trial studies light-scattering spectroscopy in finding disease in patients with stage II-III breast cancer. Diagnostic procedures, such as light-scattering spectroscopy, may help find and diagnose breast cancer

Detailed description

PRIMARY OBJECTIVES: I. To evaluate whether light-scattering spectroscopy can reliably distinguish between two subject groups: those with clinical stage II or stage III breast cancer and those without breast cancer. OUTLINE: Patients undergo light-scattering spectroscopy of the breast in addition to standard of care as it relates to screening for breast cancer or treatment of breast cancer.

Interventions

PROCEDURElight-scattering spectroscopy

Undergo light-scattering spectroscopy

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Participants who are breast cancer free (mammogram negative within 1 month of testing) with the absence of clinical suspicion of breast cancer on physical exam or with clinical stage II or stage III breast cancer. PLEASE NOTE: Recruitment for this study is only limited to patients who are scheduled for a mammogram at USC. There is no compensation to participants. * Provision of informed consent prior to any study-related procedures

Exclusion criteria

* Females with tattoos on either or both breasts * Females with nipple piercings on either or both breasts * Females with skin piercings (aka microdermal anchor surface or microdermal piercings) in either or both breasts * Females unable to provide informed consent * Females s/p treatment for breast cancer

Design outcomes

Primary

Measure	Time frame	Description
Accurate classifications of women with or without breast cancer	Up to 1 year	Exact binomial probabilities will be used.
Utility of optical markers in distinguishing cancer involved breasts from normal breasts	Up to 1 year	Multivariate analyses will be used.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026