Biological Monitoring of Nano Sized Particles in the Airways of Asthmatic Children

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01754948

Acronym

EHF

Enrollment

100

Registered

2012-12-21

Start date

2012-07-31

Completion date

2013-06-30

Last updated

2012-12-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma

Keywords

asthma, reactive airway disease, cough, air pollution, nano particles

Brief summary

Background Ambient airborne particulate material (PM) is defined according the aerodynamic diameter into coarse, fine, and ultrafine or nano sized particles ranging between 2.5-10 µm (coarse), \<2.5 µm (fine), and \<0.1 µm (nano(. Many studies have examined particle effect on respiratory health in children, mainly by environmental monitoring of coarse and fine particles. Biological assessment of individual exposure to nano sized particles in correlation to adverse health effect was not previously studied. Hypothesis individual exposure to nano sized particles in children is associated with reduction in forced expiratory volume at one second.

Interventions

None listed

Study design

Observational model

ECOLOGIC_OR_COMMUNITY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

6 Years to 18 Years

Healthy volunteers

Yes

Inclusion criteria

* age 6-18 years * living in the Tel Aviv area * referred to the pulmonology lab for respiratory function evaluation

Exclusion criteria

* Exposure to cigarette smoke * Respiratory infection in the 4 weeks prior to recruitment and testing

Design outcomes

Primary

Measure	Time frame	Description
spirometry values	1 sec	forced expiratory volume at one second

Secondary

Measure	Time frame	Description
methacholine and adenosine challenge test results	1 sec	provocative concentration causing a 20% fall in forced expiratory volume at one second and provocative dose causing a 20% fall in forced expiratory volume at one second

Countries

Israel

Contacts

Primary ContactShira Benor, MD

shirabenor@yahoo.com+972527360276

Backup ContactElizabeth Fireman, Phd

lizzyf@tlvmc.health.gov.il

Outcome results